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Important Safety Information (ISI) — GLP-1 Receptor Agonists
GLP-1 receptor agonists (semaglutide, tirzepatide, liraglutide) are FDA-approved prescription medications. They are not appropriate for everyone. Do not use if you or a family member have a history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
Serious risks include: pancreatitis, gallbladder problems, kidney problems, hypoglycemia (in patients using insulin or insulin secretagogues), heart rate increase, suicidal ideation and behavior, and serious allergic reactions. Tell your provider about all medications you take and all medical conditions.
The most common side effects are nausea, diarrhea, vomiting, constipation, and stomach pain. These are usually mild and decrease over time.
Not for use in patients with type 1 diabetes. If you experience severe abdominal pain, stop the medication and seek immediate medical attention. For full prescribing information, consult your Meridian Health provider.